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From Science to Diagnosis

Advancing respiratory medicine with leading medical institutions

The Innovation of Oxygen Deficit

How you can use oxygen deficit as the first and primary measure of pulmonary health.

Because of the logistical barriers, use of the A-a gradient has declined in favor of other less precise, but more accessible indices of oxygenation and pulmonary gas exchange. The barrier to this important clinical information has finally been removed with the validation of the Oxygen Deficit, a new non-invasive approach to a traditionally unpleasant and logistically complicated procedure.

Screenshot 2024-03-04 at 17-57-48 Oxygen Deficit White Paper.pdf

Gas Exchange Analysis to Detect Pulmonary Embolism

Pulmonary embolism (PE) is a type of venous thromboembolism (VTE) in which a clot or other obstruction breaks off and moves to the pulmonary vasculature and results in reduced pulmonary gas exchange.

Beyond Pulse Oximetry

There is no question that stand-alone pulse oximetry has become a standard in modern healthcare. It is as ubiquitous as the stethoscope, and as heavily relied upon as the electrocardiogram. That makes it all the more concerning that suddenly, in the midst of the largest respiratory crisis the world has ever faced, healthcare providers are wondering if this long-held lynchpin of healthcare monitoring is leading them astray.

Screenshot 2024-03-04 at 17-58-36 MP-July-2020-Beyond-Pulse-Oximetry-to-Pulmonary-Gas-Exchange-Measurement-in-COVID-19-71320.pdf

Short of Breath and Short on Time

Patients in respiratory distress require immediate medical attention. The ability to quickly identify hypoxemia and its cause is crucial for positive patient outcomes. However, there is a gap in the current cardiorespiratory assessment toolkit that leaves clinicians unable to quickly identify the cause and severity of hypoxemia.

Select Publications

Go West: translational physiology for noninvasive measurement of pulmonary gas exchange in patients with hypoxemic lung disease. Pickerodt P.A., & Kuebler W.M. American Journal of Physiology, Lung Cellular and Molecular Physiology. 2019 Mar 6;316: L701–L702.

A New, Noninvasive Method of Measuring Impaired Pulmonary Gas Exchange in Lung Disease: An Outpatient Study. West J.B., Crouch D.R., Fine J.M., Makadia D., Wang D.L., Prisk G.K. CHEST. 2018;154(2), pp. 363-369.

Measurements of pulmonary gas exchange efficiency using expired gas and oximetry: results in normal subjects. West, J.B., Wang, D.L., Prisk D.K. American Journal of Physiology-Lung Cellular Molecular Physiology. 2018 Apr 1;314(4): L686-L689.

Noninvasive measurement of pulmonary gas exchange: comparison with data from arterial blood gases. West, J. B., Wang, D. L., Prisk, G. K., Fine, J. M., Bellinghausen, A., Light, M. P., & Crouch, D. R. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2018.

A lifetime of pulmonary gas exchange. West, J.B. Physiological Reports. 2018 Oct;6(20):e13903.

Measuring the efficiency of pulmonary gas exchange using expired gas instead of arterial blood: comparing the “ideal” Po2 of Riley with end-tidal Po2. West JB, Liu MA, Stark PC, Prisk GK. American Journal of Physiology-Lung Cellular and Molecular Physiology 2020;319(2):L289-L293.

Validation of a Non-invasive Assessment of Pulmonary Gas Exchange During Exercise in Hypoxia. Ainslie, Philip N., Howe, Connor A., MacLeod, David B., Wainman, Liisa, Oliver, Samuel J., CHEST. 2020 Apr.

Summaries of Clinical Research

Trusted research partners demonstrate the importance of speed and accuracy of the MediPines AGM100.
A New, Noninvasive Method of Measuring Impaired Pulmonary Gas Exchange in Lung Disease: An Outpatient Study

John B. West, et al.

This new, noninvasive method of measuring impaired gas exchange in patients with lung disease is very sensitive to the presence of disease and may discard the need for arterial punctures in many instances.

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Validation of a Non-invasive Assessment of Pulmonary Gas Exchange During Exercise in Hypoxia

Philip N. Ainslie, et al.

This study found that pulmonary gas exchange efficiency measured using a non-invasive gas exchange monitor provided a valid and reliable measure against directly measured arterial blood gasses at rest and during hypoxic exercise.


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Predicting Deterioration in Gas Exchange Non-invasively Using the Alveolar Gas Meter

John B. West, et al.

The oxygen deficit (a surrogate for the alveolar-to-arterial oxygen difference) as calculated by the alveolar gas meter provides a useful tool for clinical triage.

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