MediPines aligns with emerging Rural Health Transformation Program (RHTP) priorities by enabling rapid, point-of-care respiratory triage and immediate care decisions, allowing primary care and rural sites to act without relying on delayed or inaccessible hospital-based or specialist diagnostics such as ABGs and PFTs/spirometry.
Rural COPD care model, bridging the diagnostic gap at the point of care →
Download Equipping Rural America with 21st Century COPD care.
Designed for real-world settings where pulmonary diagnostics and cardiorespiratory baselining are often unavailable, leading to unnecessary delays and sub-optimal care at the site of service.
Relevant for health system leaders overseeing rural health, population health, and care delivery strategy.
Every rural encounter contains a judgment call that urban systems take for granted: escalate the patient, or manage locally? Without an objective respiratory signal, that decision rests on incomplete proxies, SpO2, clinical impression, vitals, that routinely miss early deterioration.
The consequences compound in rural settings: a wrong call in either direction means an avoidable transfer, an unnecessary admission, or a patient discharged too soon. The AGM100 resolves this with a direct measurement of gas exchange, the actual physiological mechanism behind respiratory failure, not a surrogate for it.
Economic Impact
Respiratory conditions are among the highest-cost categories in healthcare, with 30-day readmission rates near 17% and average readmission costs of $16,400 for respiratory system diseases (AHRQ, 2023). The incremental cost of a readmission, relative to the initial admission, is approximately $3,700. Earlier, more accurate triage at the point of care can meaningfully reduce avoidable escalation and downstream cost.
Hospitals using the AGM100 in primary care and emergency departments create a rare dynamic in healthcare: better care, lower cost, and no added financial burden to adopt and deploy.
In about one minute, the AGM100 gives clinicians the gas exchange data they need to make the three most consequential decisions in respiratory care confidently, at the point of care, without a blood draw or specialist referral.
"We're measuring patients in the ER as a form of triage to determine what kind of care we're going to provide. So far it's been extremely successful. We're intervening much quicker to find out what's going on and then treating them."Head of Respiratory Therapy · Milwaukee Area Hospital
Rural populations carry higher rates of COPD, heart failure, and pulmonary disease — yet many patients go undiagnosed until an acute event forces the issue. A brief AGM100 assessment at any visit surfaces gas exchange impairment that standard vitals miss entirely.
The AGM100 was designed for care environments where lab infrastructure is limited, specialists are hours away, and care teams are spread across geographies. It requires no network connection to operate, no blood draw, and no specialist to interpret the result.
"With AGM100 alone, I can manage her. I'm not depending on my clinical impression, I'm depending on objective science. I have tests to guide my clinical suspicion."Ascension Affiliated Pulmonologist
AGM100's Oxygen Deficit metric has been validated in NIH-funded research against the best predictive tools for respiratory failure in the published literature and outperforms them all.
This level of performance enables real-time triage decisions without reliance on delayed or invasive testing.
| Year | Tool | Method | AUROC | Sens. | Spec. | Workflow Implication |
|---|---|---|---|---|---|---|
| 2010 | LIPS | Risk factor scoring | 0.82–0.84 | 69% | 78% | Limited to ALI/ARDS; requires multiple risk factor assessment |
| 2016 | ROX Index | SpO₂ + RR + FiO₂ | 0.74–0.76 | — | — | Requires high-flow O₂ patients; serial assessments at 2h, 6h, 12h |
| 2021 | Deep Learning | AI algorithms | 0.88–0.90 | — | — | Complex AI infrastructure; substantial data dependency; ongoing |
| 2025 | AGM100 | Oxygen Deficit (non-invasive) | 0.94 | 81% | 94% | Stand-alone, non-invasive. Point of care. Valid for all cardiorespiratory dyspnea. ~1–2 min. |
★ Highest reported prognostic performance for any noninvasive respiratory metric
Source: NIH-funded study | J. Clin. Med. 2025, 14, 5880
The AGM100 addresses the core objectives of the OBBBA Rural Health Transformation program directly. A dedicated AMA CPT® code (OPPS APC 5734) ensures continued reimbursement well after the grant period ends.
Chronic disease management
Objective respiratory baselines for COPD, heart failure, and pulmonary comorbidities enabling proactive management rather than reactive hospitalization.
Rural care infrastructure
Standardizes escalation decision-making across Critical Access Hospitals, primary care clinics, and long-term care settings without requiring lab infrastructure.
Reducing avoidable utilization
Early risk stratification keeps lower-acuity patients out of inpatient beds and higher-cost settings reducing unnecessary transfers and admissions.
Sustainable reimbursement
AMA CPT® code covering cardiorespiratory status baseline, non-invasive blood oxygenation, and gas exchange impairment mapped to OPPS APC 5734. Clinical and economic viability extends beyond the grant period.
The AGM100 is supported by a dedicated AMA CPT® code covering non-invasive cardiorespiratory assessment, with reimbursement pathways through Medicare, Medicaid, and commercial payers.
No net cost to the provider, supported by grant funding and established reimbursement pathways.
We'd welcome a brief conversation or are happy to connect with the appropriate member of your team overseeing population health, ACO initiatives, or rural program deployment.
